It has been reported that VAT Treg cell population shows a substantial reduction in diet‐induced obesity,[9, 20] and VAT Treg cells are known to improve obesity‐associated inflammation and insulin resistance.[9] Therefore, we further investigated whether butyrate could affect VAT Treg cells and metabolic inflammation in high‐fat diet (HFD)‐induced obese mice and whether this effect was via the butyrate‐PPARγ axis. This evidence concerns the gene PPARG and Obesity.