PPARG and obesity due to melanocortin 4 receptor deficiency: It has been reported that VAT Treg cell population shows a substantial reduction in diet‐induced obesity,[9, 20] and VAT Treg cells are known to improve obesity‐associated inflammation and insulin resistance.[9] Therefore, we further investigated whether butyrate could affect VAT Treg cells and metabolic inflammation in high‐fat diet (HFD)‐induced obese mice and whether this effect was via the butyrate‐PPARγ axis.