WNK2 and fibrosarcoma: The intrinsic activity of native LF involves inactivation of mitogen- activated protein kinase kinases (MEKs), which shuts down the RAS-RAF-MEK-ERK (Rat Sarcoma—Rapidly Accelerated Fibrosarcoma—Mitogen-Activated Protein Kinase Kinase—Extracellular Signal-Regulated Kinase) signalling pathway [98,99].