Although our observational study design did not identify the cause of the patient’s persistent and uncontrolled KSHV viremia, correlation analysis indicated some positive correlations between KSHV VL and HIV VL over the study period, concomitant with a negative correlation with CD4 count, indicating that the KSHV VL increased with a worsening HIV infection (Supplementary Figure S1). This evidence concerns the gene CD4 and HIV infectious disease.