aβ is a neurotoxic peptide formed by the excision of the β-site cleavage enzyme 1 (BACE1) and γ-secretase complex of the β-amyloid precursor protein from amyloid precursor protein (APP), which serves as a marker of early cognitive deficits and is considered an important target for regulating cognitive deficits [93]. The gene discussed is BACE1; the disease is Cognitive impairment.