Noteworthy ones include a study of patients with late-onset AD showing a higher rate of differential expression of CHI3L2 in males exhibiting depression as a comorbidity [87], a review of epigenetic changes currently associated with age-related disorders highlighting investigations of AD and PD in both human and animal models [88], and a study finding epigenetic changes in a CpG site near the KALRN gene previously associated with AD [89]. This evidence concerns the gene KALRN and depressive symptom measurement.