To assess the impact of apigenin on the activities of key caspases (caspase-8, -9, and -3/7) in CCA cells, KKU-M055 cells were treated with an IC50 concentration of apigenin for 24 h, and caspase activities were measured using the Caspase-Glo kits. Here, CASP8 is linked to cholangiocarcinoma.