In NY8.3 NOD mice expressing the islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP)–reactive CD8+ T cell receptor, both the microbial mimitope and the Fusobacteria itself activate IGRP206–214-specific NY8.3 CD8+ T cells and drive T1D development [133]. This evidence concerns the gene CD8A and type 1 diabetes mellitus.