There are studies in animal models such as that of Bjursell et al. in 2011, in which they showed that in mice transgenic for GPR43, there is an improvement in metabolic parameters, such as reduced obesity, increased homeostasis, increased quality of lean mass, and increased secretion of GLP-1 [177,185,186]. Here, FFAR2 is linked to obesity due to melanocortin 4 receptor deficiency.