In AD, quercetin acts on the heat shock protein beta-1 (HSPB1), the redox-sensitive transcription factor Nrf2, and the neurotrophins receptor tropomyosin receptor kinase B (TRKB), inhibiting Tau aggregation and protecting differentiated neuronal cells from the neurotoxicity of hyperphosphorylated Tau [211]. Here, MAPT is linked to Alzheimer disease.