APP and Alzheimer disease: It is known that the expression of γ-secretase and β-secretase can be inhibited through the binding of PPARγ to the promoter region of the BACE1 gene, subsequently suppressing the generation of Aβ since Aβ peptides are derived from the sequential break of the amyloid protein precursor (APP), an essential single transmembrane protein, by BACE1, providing the possible development of AD.