Ginsenoside Rg1 not only down-regulates GAS5 expression through GAS5/EZH2/SOCS3/NRF2, reduces microglial activation, and improves mitochondrial dysfunction in depression but also alleviates acute ulcerative colitis by regulating the intestinal flora and microbial tryptophan metabolism [6,7]. This evidence concerns the gene GAS5 and major depressive disorder.