In a study that enrolled 699 patients with T1DM/T2DM+DN and diabetic foot ulcers and 2695 controls (patients with T1DM/T2DM+DN, but without foot ulcers), the single-nucleotide polymorphism rs80028505 (Chr6p2131) in MAPK14 reached genome-wide significance. This evidence concerns the gene MAPK14 and liver dysplastic nodule.