Notably, HCC patients carrying the VEGF-C polymorphic genotype rs3775194 GC/CC exhibit a lower prevalence of positive liver cirrhosis tests, while individuals with the VEGF-C polymorphic genotype rs7664413 CT/TT are at an elevated risk of developing advanced clinical stages (III or IV) compared to those with the homozygous C/C genotype [45]. This evidence concerns the gene VEGFA and hepatocellular carcinoma.