MAPT and Alzheimer disease: Work has shown that, in cognitively impaired participants, FTP is directly correlated with language, executive function, and visuospatial performance in the regions localizing with established brain–behavior relationships [49], and, in non-demented participants, RO948-detected tau in the Brodmann area 35, entorhinal cortex, and anterior hippocampus is associated with Alzheimer’s Disease Assessment Scale-Cognitive (ADAS) delayed memory performance [40].