Furthermore, [18F]RO948 and temporal ROI-detected tau were associated with MMSE in patients with amnestic MCI or mild dementia [74], an FTP-detected neorcortical tau predicted longitudinal change in MMSE across a spectrum of AD clinical presentations [75]; both FTP and RO948-detected baseline temporal tau were associated with MMSE decline [70], and THK5317-detected baseline middle temporal tau strongly predicted change in MMSE [76]. This evidence concerns the gene MAPT and Alzheimer disease.