Work done by Biel et al. investigating the application of fMRI-derived meta-analytical cognitive maps to FTP tau PET images found that the assessment of tau deposition in cognitive-domain-specific regions outperforms more conventional tau–PET metrics and, when paired with personalized cognitive measures, is more sensitive to AD-related cognitive decline with respect to episodic memory, language, executive functioning, and visuospatial metrics [71]. This evidence concerns the gene MAPT and Mental deterioration.