A study with GTP1 tau PET found that baseline tau was significantly associated with yearly global cognitive change, as measured by the Mini-Mental State Exam (MMSE), Clinical Dementia Rating Sum of Boxed (CDR-SB), 13-item version of the AD Assessment Scale-Cognitive Subscale (ADAS-Cog13), and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) Total Index, independent of cortical volume or Aβ-PET. The gene discussed is MAPT; the disease is Alzheimer disease.