In a study analyzing approximately 81,000 genomes, researchers identified unique genetic variations in these two genes across different populations, where an ACE2 polymorphism (p.Arg514Gly) in African/African-American populations was linked to cardiovascular and pulmonary conditions, and a prevalent polymorphism in TMPRSS2 (p.Val160Met) was associated with an increased risk of severe COVID-19, especially in male patients and those with cancer. This evidence concerns the gene TMPRSS2 and COVID-19.