ACE2 and COVID-19: In another study conducted on 317 patients in Egypt, no significant link was found with the ACE2 rs2285666 polymorphism, while the TMPRSS2 rs12329760 polymorphism, specifically the T allele and CT/TT genotypes, was associated with a lower risk of severe COVID-19, which suggests that TMPRSS2 variations may play a protective role in disease severity [14].