The intersection of this pathway in patients with IPF and PJ was formed by the DEPs aldehyde dehydrogenase 2 (ALDH2) (upregulated), aldehyde dehydrogenase 3A1 (ALDH3A1) (downregulated), fructose-bisphosphatase 1 (FBP1) (upregulated) and triosephosphate isomerase 1 (TPI1) (upregulated), and we hypothesize that they could be essential in regulating the interaction with the AKT/GSK-3β/snail pathway and the development of lung fibrosis among these patients. This evidence concerns the gene TPI1 and idiopathic pulmonary fibrosis.