The omega-3 fatty acids group had a significantly lower incidence of the recurrence of bipolar depression compared to those in the placebo group. A lower HDRS score was noted in the omega-3 fatty acids group at the 2nd, 3rd, 4th, 5th, and 6th months.Omega-3 fatty acids were associated with increased levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, and blood urea nitrogen. The gene discussed is GPT; the disease is bipolar disorder.