PSP had reduced acetylcholinesterase (AChE) activity in the paracentral region and the thalamus [166] and frequently shows frontal hypometabolism, although it varies in severity and pattern across PSP variants; it is common in PSP-SL, PSP-CBS, and PSP-F and least common in PSP-PGF, while PSP-SL and PSP-CBS show more severe hypometabolism than PSP-RS, PSP-P, and PSP-PGF. This evidence concerns the gene ACHE and supranuclear palsy, progressive, 1.