Among 50 autopsy-proven MSA cases (33 MSA-P, 15 MSA-C) with a mean age at death of 60.5 ± 7.8 years, moderate CI in 35% and severe dementia in a single case, moderate cortical tau pathology (Braak II-III) was seen in 30%, PART and AD (Braak V) in one case each. Here, MAPT is linked to multiple system atrophy.