When the lysates from the excised tumors were immunoblotted, there was an apparent decrease in MGMT protein levels; this decrease was accompanied by enhanced levels of both the cleaved PARP and cleaved caspase-3 in tumors verifying that hGTX along with the alkylating agents triggered apoptotic cascades in tumor tissues (Figure 12C). The gene discussed is CASP3; the disease is neoplasm.