Further, the MGMT activity in tumor lysates was also diminished considerably after treatment with the combinations of hGTX and cisplatin, hGTX + BCNU in T98G xenografts and hGTX + TMZ, NCX + BCNU, and NCX + TMZ combinations in the HT-29-luc2 (Figure 14), reflecting the greater alkylation DNA damage incurred in vivo. This evidence concerns the gene MGMT and neoplasm.