In this regard, Wang et al. fabricated a highly sensitive ISFET biosensor on a silicon substrate for the rapid detection of cardiac troponin I (cTnI) which paved the way for diagnosing acute myocardial infarction (AMI), a life-threatening cardiovascular condition as depicted in schematic overview of bio-ISFET in Figure 3a,b [70]. This evidence concerns the gene TNNI3 and acute myocardial infarction.