Current ENETS and North America NeuroEndocrine Tumor Society (NANETS) guidelines strongly recommend surgical resection for neoplasms larger than 2 cm, those with aggressive features (i.e., G2–G3, Ki-67 > 5% or local invasion), or in the case of F-pNENs causing symptoms due to hormonal secretion [3,34]. This evidence concerns the gene MKI67 and neoplasm.