The tumor was diffusely positive for CAM5.2, AE1/AE3, focally positive for PAX8, and negative for CK7, CD10, MART, TTF-1, Desmin, Calretinin, GATA3, ER, Inhibin, CK20 and EMA, with Ki-67 proliferative index > 80% (Figure 1D,E). The gene discussed is PAX8; the disease is neoplasm.