SOD3 and neoplasm: It was found in a murine model that the overexpression of the extracellular superoxide dismutase 3 (SOD3) in the endothelial cells of tumor vasculature conferred transcriptional induction of laminin α4; subsequent embedding of laminin α4 into the subendothelial basement membrane facilitated the transmigration of T cells from intratumor vessels into the stroma, thereby boosting T-lymphocyte infiltration of tumors [64].