The implication of monocyte-derived macrophages in TME remodeling is established: stromal macrophages may undergo pro-tumor M2 polarization and then contribute to tumor progression and metastasis by generating growth factors such as TGFβ, VEGF, EGF, FGF, and PDGF; proinflammatory factors such as TNFα, IL1β, IL6, and IL12; and immunosuppressive factors such as IL10 and PGE2 [39,40]. This evidence concerns the gene EGF and neoplasm.