Taking into account that it is TGFβ that is a master regulator of cellular pathways resulting in fibrosis, the synthesis/secretion of TGFβ, TGFβ-receptors, and TGFβ-related signaling seem to be the relevant parameters/targets in the context of fighting the fibrotic tightness of tumor stroma [107]. This evidence concerns the gene TGFB1 and neoplasm.