Later, Zhao et al. constructed mesothelin-specific CAR-T cells overexpressing a secreted form of human hyaluronidase PH20; thanks to the conferred hyaluronidase overexpression/secretion, those anti-mesothelin CAR-T cells exhibited better infiltration into tumors and repressed tumor growth in mice with gastric cancer xenografts [94]. This evidence concerns the gene MSLN and gastric cancer.