Post-exercise, there was increased mRNA expression of BDNF, Glial Cell-Derived Neurotrophic Factor (GDNF), TFAM (mitochondrial transcription factor A), and Ndufa6 (mitochondrial complex I subunit), as well as increased phosphorylation of the cAMP response element-binding protein, suggesting that exercise reduces anxiety-like behaviors and may exert antidepressant-like effects in mice, promoting neuroplasticity and improving mood [90]. The gene discussed is TFAM; the disease is Anxiety.