MMP2 and neoplasm: However, given the data on the high serum GFAP levels in such patients [5], circulating EVs with the GFAP+VEGF+bright MMP2+C5b-9+ phenotype can be considered as a mixed fraction of tumor-specific EVs and a subfraction of the total pool of plasma EVs, with accumulation of the four biomarkers GFAP, VEGF, MMP2, and C5b-9 on their surface.