When analyzing the phenotypes of GFAP-positive EVs, statistical differences were found in the content of vesicles with the VEGFdim+MMP2+C5b-9- and VEGFdim+MMP2-C5b-9+ phenotype between patients with recurrent and non-recurrent GBM (p < 0.05) (Table 2). The gene discussed is MMP2; the disease is glioblastoma.