A comparative statistical analysis revealed significant associations between KRAS mutation and some clinicopathological features, such as tumour histological pattern (p = 0.018), tumour grade (p = 0.030) depth of invasion (pT) (p < 0.001), lymph node involvement (pN) (p < 0.001), and tumour budding (p = 0.007). This evidence concerns the gene KRAS and neoplasm.