A comparative statistical analysis between the KRAS mutation status and tumour clinicopathological features revealed significant associations between KRAS mutation and mixed tumour histology (p = 0.018), tumour grade (p = 0.030), tumour invasion depth (pT) (p < 0.001), advanced stage or N2 lymph node metastasis (p < 0.001), venous vascular invasion (p = 0.048), and high index of tumour budding (p = 0.007) (Table 2 and Table 3). The gene discussed is KRAS; the disease is neoplasm.