Based on brain (ATP5MC3, GOT1, SAT1, EGFR, and MAPK9) and blood (G6PD, PGD, ALOX5, HMOX1, and ULK1) features, a TWAS analysis was conducted in conjunction with AD GWAS (GCST007320 and ukb-b-323) to investigate genes associated with the risk of AD. This evidence concerns the gene HMOX1 and Alzheimer disease.