IRF4 and chronic rhinosinusitis with nasal polyps: The MIAT/miR-125a/IRF4 axis plays a critical role in CRSwNP pathogenesis by regulating immune cell infiltration and inflammatory responses. IRF4 and MIAT show high predictive value for CRSwNP diagnosis (AUC = 0.944), offering potential as diagnostic biomarkers and therapeutic targets. Interventions targeting this axis may mitigate eosinophil-driven inflammation and tissue remodeling in CRSwNP