The upregulation of miRNAs linked to mucin-type O-glycan biosynthesis suggests a role in excessive mucus production in CRSwNP, while the downregulation of miRNAs targeting TGF-β and MAPK signaling pathways highlights their involvement in tissue remodeling and inflammation. These miRNAs may serve as targets for modulating these pathways in future therapeutic approaches. The gene discussed is MUC5AC; the disease is chronic rhinosinusitis with nasal polyps.