In CRC mice treated with anti-CTLA-4 and Lactobacillus acidophilus lysates, tumor reduction was associated with increased IL-2, IFN-γ, and CD8+ T cell infiltration, with Bifidobacterium upregulating tumor-specific CD8+ T cells and IFN-γ secretion [157]. The gene discussed is CD8A; the disease is colorectal carcinoma.