Due to its critical role in maintaining immune homeostasis, the dysregulation of LL-37 activity has been implicated in the onset and progression of numerous human diseases, such as the severe periodontal disease observed in Kostmann disease patients and Papillon-Lefevre syndrome, who lack or have very low levels of LL-37 [7,8,9]. The gene discussed is CAMP; the disease is Papillon-Lefevre disease.