COL3A1 and Ehlers-Danlos syndrome, vascular type: Vascular Ehlers–Danlos syndrome (vEDS) is a severe form of EDS caused by heterozygous pathogenic variants in COL3A1, with a common phenotypic presentation of cigarette paper-like scarring, translucent skin, easy bruising over bony protuberances, and laxity of finger joints [12].