CASP1 and metabolic syndrome: For instance, DHA can reverse and/or attenuate the pro-inflammatory effect of free palmitate mediated by toll-like receptors (TLR)/inflammasome, and it reduced lipid accumulation and inflammation by suppressing NOD-like receptors and caspase-1 activation in HepG2 cells [62], which is a mechanism involved in the cardiometabolic effect associated with the metabolic syndrome.