Prior studies have suggested that blocking tumor-cell-intrinsic PD-L1 can cause DNA damage, as marked by an increase in γH2AX [16,19], and that STING can be subsequently activated after DNA damage, leading to cycle arrest through increased p21 [20] and apoptosis via caspase-3 cleavage [22] in other tumor cells. This evidence concerns the gene CD274 and neoplasm.