Additionally, an immunohistochemical analysis in skin and lymph node samples from 52 patients with CTCL highlighted the increased CD38 expression in skin biopsies from aggressive CTCL subtypes such as SS with large-cell transformation, primary cutaneous γδT-cell lymphoma, and primary cutaneous NK/T-cell lymphoma, negatively correlating with overall survival [44,46]. The gene discussed is CD38; the disease is T-cell non-Hodgkin lymphoma.