Specifically, NXPH1 regulates synaptic plasticity [42], while CRTC1 has been linked to aging-related disorders such as Alzheimer’s disease [76] and regulates gene expression related to dendritic maturation and inflammation to promote blood–brain barrier integrity, memory, and learning [43,44,77]. The gene discussed is CRTC1; the disease is early-onset autosomal dominant Alzheimer disease.