NEMO oligomerizes and interacts with other proteins, such as IKK kinase subunits and IκB, via different domains, and its functional deficiencies in mediating NF-κB activation, which are caused by numerous mutations, are associated with inherited diseases, such as incontinentia pigmenti (IP), ectodermal dysplasia, and anhidrotic, with immunodeficiency (EDA-ID), and some cancers (robust details on NEMO’s domain composition, interaction proteins, and disease-associated mutations can be seen in the review article [21]). This evidence concerns the gene NFKB1 and incontinentia pigmenti.