It is worth mentioning that an increased expression of mesenchymal markers such as Vimentin, αSMA, SNAIL and TWIST was observed in adiponectin-treated TR MCF-7 cells, addressing the activation of the EMT program in breast cancer cells, which sustains the generation of hormone-resistant breast cancer stem cells, as previously documented [62,63]. The gene discussed is ADIPOQ; the disease is breast carcinoma.