Recently, various studies have established that TAMs and sCD163 have a crucial role in the pathogenesis of many hematopoietic malignancies such as Multiple myeloma (MM) [15,26,27], Hodgkin lymphoma (HL) [28,29], Chronic Lymphocytic leukemia (CLL) [30], and Diffuse B-cell large lymphoma (DLBCL) [31,32]. The gene discussed is CD163; the disease is B-cell chronic lymphocytic leukemia.