Moreover, we examined the correlation of sCD163, CCL2 and CCL4 with clinical factors of WM and the following correlations were revealed; bone marrow infiltration was correlated with both sCD163 (0.249, p = 0.04) and CCL2 (0.272, p = 0.043), and occurrence of splenomegaly was associated with CCL4 (0.311, p = 0.023). This evidence concerns the gene CCL4 and Splenomegaly.