ERβ activation by agonists was indeed able to exert an antiproliferative effect, both in vitro, in a panel of HL cells, and in vivo, in non-obese diabetic/severe combined immunodeficient (NOD/SCID) mice engrafted with HL cells, by triggering the DNA damage-regulated autophagy modulator 2 (DRAM2)-dependent autophagic cascade [102]. This evidence concerns the gene ESR2 and Hodgkins lymphoma.