Other studies have also shown that GANT61, by blocking Gli functions, represses cell proliferation in several tumors, making it a good candidate for the treatment of hematological malignancies, including myelodysplastic syndromes and acute myeloid leukemia (AML), where treatment with GANT61 blocks the cell cycle in the G1/G0 phase in a dose- and time-dependent manner [26]. The gene discussed is GLI1; the disease is hematologic disorder.