In AML cells with a mutated form of FLT3, a non canonical activation of Gli via FLT3 and PI3K has been found, since the inhibition of FLT3 and PI3K reduces Gli protein expression, whereas in AML cells of wildtype FLT3, Gli expression seems to be activated in a canonical manner [83]. This evidence concerns the gene FLT3 and acute myeloid leukemia.