In HL-60 acute myeloid leukemia cell line, cyclopamine (Smo inhibitor) induced apoptotic cell death, cell cycle arrest in the G0/G1 phase, and monocytic differentiation (a strategy often used for the treatment of hematological malignancies), also causing downregulation of pAkt and ERK1/2, involved in anti-proliferative activity [27]. This evidence concerns the gene SMO and acute myeloid leukemia.