They also observed that Smo inhibition alone did not influence CLL cell survival, while the Gli inhibitor GANT61 caused significant apoptosis in CLL cells but not in normal B cells, suggesting that expression of the transcription factor Gli1, a key element of the Hedgehog (Hh) pathway, is thus regulated by several pathways, such as the PI3K/Akt, RAS/RAF/MEK/ERK, Wnt/β-catenin, Notch or Hippo pathways, that act upstream through post-translational mechanisms, indirectly modulating the expression of genes critical for cell proliferation and survival [51]. The gene discussed is SMO; the disease is B-cell chronic lymphocytic leukemia.