MAPT and Alzheimer disease: Furthermore, Pietronigro et al. demonstrated that neutrophil-specific protease cathepsin G accumulates in the brain and blood vessels of AD patients [66], while Zenaro et al. confirmed the infiltration of neutrophils into the brains of AD mice and observed that neutrophil extracellular traps (NETs) promoted amyloid plaque formation and tau tangles, leading to worsened cognitive decline [67].