In order to shed light on the role of PPRC1 in carcinogenesis, a comprehensive analysis of transcriptomic and genomic databases was performed and demonstrated the following: (1) PPRC1 expression is significantly higher in most cancer types tested, (2) high PPRC1 expression was correlated with short OS in multiple cancers, (3) PPRC1 gene alterations significantly correlated with short OS and/or DFS of several types of cancer, (4) PPRC1 prognostic power is independent of mutations in well-known tumor suppressors/oncogenes. Here, PPRC1 is linked to neoplasm.