To test whether the prognostic power of PPRC1 is driven by the association with key tumor suppressors/oncogenes, such as TP53, PIK3CA, and PTEN, we have removed from our patient cohort all cancer patients (9919 cases) that carry these genetic alterations and re-analyzed the data with respect to the correlation of PPRC1 genetic alterations with overall survival. The gene discussed is PIK3CA; the disease is cancer.