SLC4A7 and Fuchs endothelial corneal dystrophy: In this respect, ripasudil and netarsudil showed no significant differences, as indicated by equally upregulated expression levels of key genes important for ion and water transport, specifically sodium–potassium pump subunits, bicarbonate transporters, monocarboxylate transporters, and chloride transporters, and by the enhanced Na+/K+-ATPase enzyme activity in both primary cell cultures and surgically excised EDM specimens from FECD patients.