We first interrogated the gene expression profiles of ST14, PRSS8, SPINT1, and SPINT2 (SPSS) in a cohort of eight common carcinomas of epithelial origin in the TCGA Pan-Cancer (PANCAN) dataset using the UCSC Xena Functional Genomics Browser (University of California Santa Cruz, https://xenabrowser.net/, accessed on 20 December 2024). The gene discussed is SPINT2; the disease is carcinoma.