Interleukin-8 (IL-8), a key chemokine that amplifies inflammatory responses by recruiting and activating neutrophils, plays a pivotal role in the pathogenesis of AD [22], with elevated levels in keratinocytes, such as HaCaT cells, exacerbating inflammation in response to cytokines, such as TNF-α and IFN-γ, making its reduction a critical target for mitigating AD-related inflammation. The gene discussed is TNF; the disease is Alzheimer disease.