We evaluated sera from 69 Guam ALS cases collected within 2 years of symptom onset by NIH researchers from 1950 to 1983 for 11 immunoregulators via ELISA (CRP, eotaxin‐1, RANTES, IL‐6, IL‐8, IL‐10, IFN‐γ, IP‐10, MCP‐1, MCP‐2 and TARC). Here, IFNG is linked to amyotrophic lateral sclerosis.