Additionally, we isolated bone marrow‐derived macrophages (BMDMs) from 6‐week‐old C57BL/6 mice and treated cells with high glucose and palmitic acid (HG+PA; 25 mm glucose and 400 μm palmitic acid) for 48 h to imitate T2DM conditions in vitro.[31] The results showed that HG+PA treatment significantly reduced GLS expression (Figure 1F). This evidence concerns the gene GLS and type 2 diabetes mellitus.