GLS and type 2 diabetes mellitus: Epigenetic modifications control gene expression without changing the DNA sequence and are regulated by metabolites such as lactate, acetyl‐CoA, and α‐KG.[56] α‐KG serves as a cofactor for TETs, a kind of dioxygenase, which influences gene expression by modulating DNA methylation.[23, 57] In our study, glutaminolysis impairment due to T2DM or GLS deficiency reduced α‐KG levels in macrophages, inhibiting TET activity.