Moreover, compared to the Cy5.5@ALN‐Lipo group, the number of OCN+ osteoblasts increased while that of TRAP+ osteoclasts decreased in the callus of α‐KG@Cy5.5@ALN‐Lipo treated T2DM mice (Figure S8A–D, Supporting Information). The gene discussed is BGLAP; the disease is type 2 diabetes mellitus.