Compared with PBS, B7‐H3‐CD3 (5 mg kg−1), or ICAM‐1–Dxd (5 mg kg−1) (Figure 6B,D), the combination of ICAM‐1–Dxd and B7‐H3‐CD3 resulted in significant and sustained inhibition of tumor growth in tumor‐bearing model mice. Here, CD276 is linked to neoplasm.