CD276 and neoplasm: A previous study demonstrated that the TIM is closely related to various immunosuppressive factors, such as Tregs, MDSCs, and immunosuppressive cytokines.[44] B7‐H3‐CD3 bispecific antibodies help overcome these immunosuppressive factors by activating T cells and reshaping the TIM.[45] Another study characterized an IgG‐based B7‐H3‐CD3 bispecific antibody, demonstrating excellent tumor cell killing ability, T‐cell activation, proliferation, and memory formation in vitro.