As shown in Figure S3B–F, these piRNAs could regulate multiple target mRNAs related to neuroprotection against cerebral ischemia, such as epidermal growth factor receptor (EGFR), insulin‐like growth factor 1 (IGF1), cAMP response element binding protein 1 (CREB1), synaptotagmin (SYT) 1 and 2, and glutamate ionotropic receptor N‐Methyl‐D‐Aspartate type subunit (GRIN) 2A and 2B. Here, CREB1 is linked to brain ischemia.