NF2 and skull base meningioma: In summary, we developed a Cas9 mouse model of skull base meningioma initiated with a genetic defect in Nf2 and the combined loss of P15Ink4b, P16Ink4a, and P19Arf in this study that can provide a new tool for investigating the pathogenesis of meningioma and aid in devising chemical treatments for patients with this disease.