NPPB and coronary artery disorder: Urinary 5-hydroxyindoleacetic acid (5-HIAA) and NT-pro-BNP should be performed; with a cut-off level of >300 μmol/24 hours and >260 ng/L, respectively, TTE is indicated [2]. In patients with CS, the sensitivity and specificity of NT-proBNP at a cutoff level of 260 pg/mL for the detection of CHD are 92% and 91%, respectively, whereas the sensitivity of urine 5-HIAA is 35-73%, and the specificity is 89-100% depending on the cutoff used [6].